To clean up memory of unnecessary things run sync first to flush useful things out to disk.
root# sync
To free pagecache: echo 1 > /proc/sys/vm/drop_caches
To free dentries and inodes: echo 2 > /proc/sys/vm/drop_caches
To free pagecache, dentries and inodes: echo 3 > /proc/sys/vm/drop_caches